Top 100 Most-Cited Papers

The 100 most-cited papers across the Crohn's-disease literature (small bowel, ileocolic & large bowel collections), by citation count (OpenAlex).

A research reference: rankings are drawn from the published literature, not treatment advice. Always talk with your own care team about what any study means for you.

Lamb CA · 2019 · Gut · British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults.1,824 cites
Cosnes J · 2011 · Gastroenterology · Epidemiology and natural history of inflammatory bowel diseases.1,653 cites
Gomollón F · 2017 · J Crohns Colitis · 3rd European Evidence-based Consensus on the Diagnosis and Management of Crohn's Disease 2016: Part 1: Diagnosis and Medical Management.1,556 cites
Rutgeerts P · 1990 · Gastroenterology · Predictability of the postoperative course of Crohn's disease.1,458 cites
Baumgart DC · 2007 · Lancet · Inflammatory bowel disease: clinical aspects and established and evolving therapies.1,440 cites
Greenstein AJ · 1976 · Medicine (Baltimore) · The extra-intestinal complications of Crohn's disease and ulcerative colitis: a study of 700 patients.1,062 cites
Fazio VW · 1995 · Ann Surg · Ileal pouch-anal anastomoses complications and function in 1005 patients.958 cites
Frøslie KF · 2007 · Gastroenterology · Mucosal healing in inflammatory bowel disease: results from a Norwegian population-based cohort.936 cites
Peyrin-Biroulet L · 2010 · Am J Gastroenterol · The natural history of adult Crohn's disease in population-based cohorts.825 cites
Chapman RW · 1980 · Gut · Primary sclerosing cholangitis: a review of its clinical features, cholangiography, and hepatic histology.739 cites
Lichtenstein GR · 2006 · Clin Gastroenterol Hepatol · Serious infections and mortality in association with therapies for Crohn's disease: TREAT registry.720 cites
D'Haens GR · 1998 · Gastroenterology · Early lesions of recurrent Crohn's disease caused by infusion of intestinal contents in excluded ileum.682 cites
Lichtenstein GR · 2009 · Am J Gastroenterol · Management of Crohn's disease in adults.677 cites
Shah SC · 2022 · Gastroenterology · Colorectal Cancer in Inflammatory Bowel Disease: Mechanisms and Management.643 cites
Rutgeerts P · 1984 · Gut · Natural history of recurrent Crohn's disease at the ileocolonic anastomosis after curative surgery.639 cites
Rutgeerts P · 1991 · Lancet · Effect of faecal stream diversion on recurrence of Crohn's disease in the neoterminal ileum.598 cites
Rutgeerts P · 1995 · Gastroenterology · Controlled trial of metronidazole treatment for prevention of Crohn's recurrence after ileal resection.596 cites
Bernell O · 2000 · Ann Surg · Risk factors for surgery and postoperative recurrence in Crohn's disease.515 cites
Fallingborg J · 1999 · Dan Med Bull · Intraluminal pH of the human gastrointestinal tract.500 cites
Saxon A · 1990 · J Allergy Clin Immunol · A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease.479 cites
Regueiro M · 2009 · Gastroenterology · Infliximab prevents Crohn's disease recurrence after ileal resection.479 cites
Issa M · 2007 · Clin Gastroenterol Hepatol · Impact of Clostridium difficile on inflammatory bowel disease.449 cites
Lutgens MW · 2013 · Inflamm Bowel Dis · Declining risk of colorectal cancer in inflammatory bowel disease: an updated meta-analysis of population-based cohort studies.434 cites
Itzkowitz SH · 2005 · Inflamm Bowel Dis · Consensus conference: Colorectal cancer screening and surveillance in inflammatory bowel disease.423 cites
Olaison G · 1992 · Gut · Natural course of Crohn's disease after ileocolic resection: endoscopically visualised ileal ulcers preceding symptoms.413 cites
Matsuoka K · 2018 · J Gastroenterol · Evidence-based clinical practice guidelines for inflammatory bowel disease.396 cites
Gillen CD · 1994 · Gut · Ulcerative colitis and Crohn's disease: a comparison of the colorectal cancer risk in extensive colitis.389 cites
Vermeire S · 2004 · Inflamm Bowel Dis · C-reactive protein as a marker for inflammatory bowel disease.379 cites
Gajendran M · 2018 · Dis Mon · A comprehensive review and update on Crohn's disease.379 cites
Fumery M · 2018 · Clin Gastroenterol Hepatol · Natural History of Adult Ulcerative Colitis in Population-based Cohorts: A Systematic Review.368 cites
Hellers G · 1980 · Gut · Occurrence and outcome after primary treatment of anal fistulae in Crohn's disease.364 cites
Phillips EH · 1992 · Ann Surg · Laparoscopic colectomy.348 cites
Hanauer SB · 2004 · Gastroenterology · Postoperative maintenance of Crohn's disease remission with 6-mercaptopurine, mesalamine, or placebo: a 2-year trial.348 cites
Zhao M · 2021 · J Crohns Colitis · The Burden of Inflammatory Bowel Disease in Europe in 2020.343 cites
Irvin TT · 1973 · Br J Surg · Aetiology of disruption of intestinal anastomoses.326 cites
Sandborn WJ · 1994 · Gastroenterology · Pouchitis following ileal pouch-anal anastomosis: definition, pathogenesis, and treatment.319 cites
Rogler G · 2014 · Cancer Lett · Chronic ulcerative colitis and colorectal cancer.318 cites
Triantafillidis JK · 2009 · Anticancer Res · Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies.316 cites
Jess T · 2007 · Inflamm Bowel Dis · Changes in clinical characteristics, course, and prognosis of inflammatory bowel disease during the last 5 decades: a population-based study from Copenhagen, Denmark.314 cites
Rutgeerts P · 2005 · Gastroenterology · Ornidazole for prophylaxis of postoperative Crohn's disease recurrence: a randomized, double-blind, placebo-controlled trial.308 cites
Munkholm P · 1993 · Gastroenterology · Intestinal cancer risk and mortality in patients with Crohn's disease.304 cites
Malouf AJ · 2000 · Lancet · Long-term results of overlapping anterior anal-sphincter repair for obstetric trauma.303 cites
Hahnloser D · 2007 · Br J Surg · Results at up to 20 years after ileal pouch-anal anastomosis for chronic ulcerative colitis.297 cites
Charpentier C · 2014 · Gut · Natural history of elderly-onset inflammatory bowel disease: a population-based cohort study.293 cites
Colombel JF · 2004 · Am J Gastroenterol · Early postoperative complications are not increased in patients with Crohn's disease treated perioperatively with infliximab or immunosuppressive therapy.292 cites
Dunker MS · 1998 · Surg Endosc · Cosmesis and body image after laparoscopic-assisted and open ileocolic resection for Crohn's disease.290 cites
Duerr RH · 1991 · Gastroenterology · Anti-neutrophil cytoplasmic antibodies in ulcerative colitis. Comparison with other colitides/diarrheal illnesses.286 cites
Yamamoto T · 2000 · Dis Colon Rectum · Risk factors for intra-abdominal sepsis after surgery in Crohn's disease.281 cites
Bernell O · 2000 · Br J Surg · Risk factors for surgery and recurrence in 907 patients with primary ileocaecal Crohn's disease.273 cites
Lang J · 1988 · J Clin Pathol · Diaphragm disease: pathology of disease of the small intestine induced by non-steroidal anti-inflammatory drugs.272 cites
Ponsioen CY · 2017 · Lancet Gastroenterol Hepatol · Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn's disease: a randomised controlled, open-label, multicentre trial.270 cites
Coffey CJ · 2018 · J Crohns Colitis · Inclusion of the Mesentery in Ileocolic Resection for Crohn's Disease is Associated With Reduced Surgical Recurrence.266 cites
Price AB · 1978 · J Clin Pathol · Overlap in the spectrum of non-specific inflammatory bowel disease--'colitis indeterminate'.264 cites
Daniels JA · 2007 · Am J Surg Pathol · Gastrointestinal tract pathology in patients with common variable immunodeficiency (CVID): a clinicopathologic study and review.264 cites
Regueiro M · 2016 · Gastroenterology · Infliximab Reduces Endoscopic, but Not Clinical, Recurrence of Crohn's Disease After Ileocolonic Resection.264 cites
Solem CA · 2004 · Am J Gastroenterol · Venous thromboembolism in inflammatory bowel disease.263 cites
Tsai L · 2021 · Clin Gastroenterol Hepatol · Contemporary Risk of Surgery in Patients With Ulcerative Colitis and Crohn's Disease: A Meta-Analysis of Population-Based Cohorts.262 cites
Herrinton LJ · 2012 · Gastroenterology · Incidence and mortality of colorectal adenocarcinoma in persons with inflammatory bowel disease from 1998 to 2010.260 cites
Katz KD · 1989 · Gastroenterology · Intestinal permeability in patients with Crohn's disease and their healthy relatives.255 cites
Yarur AJ · 2017 · Aliment Pharmacol Ther · Higher infliximab trough levels are associated with perianal fistula healing in patients with Crohn's disease.252 cites
Kirsner JB · 1982 · N Engl J Med · Recent developments in "nonspecific" inflammatory bowel disease (first of two parts).251 cites
Roslyn JJ · 1983 · Gastroenterology · Gallbladder disease in patients on long-term parenteral nutrition.250 cites
D'Haens GR · 2008 · Gastroenterology · Therapy of metronidazole with azathioprine to prevent postoperative recurrence of Crohn's disease: a controlled randomized trial.249 cites
Alves A · 2007 · Dis Colon Rectum · Risk factors for intra-abdominal septic complications after a first ileocecal resection for Crohn's disease: a multivariate analysis in 161 consecutive patients.248 cites
Milsom JW · 2001 · Dis Colon Rectum · Prospective, randomized trial comparing laparoscopic vs. conventional surgery for refractory ileocolic Crohn's disease.247 cites
Romberg-Camps MJ · 2009 · Am J Gastroenterol · Influence of phenotype at diagnosis and of other potential prognostic factors on the course of inflammatory bowel disease.246 cites
Kulnigg S · 2006 · Aliment Pharmacol Ther · Systematic review: managing anaemia in Crohn's disease.244 cites
Tulchinsky H · 2003 · Ann Surg · Long-term failure after restorative proctocolectomy for ulcerative colitis.243 cites
Ljung T · 2004 · Gut · Infliximab in inflammatory bowel disease: clinical outcome in a population based cohort from Stockholm County.242 cites
Fazio VW · 1996 · Ann Surg · Effect of resection margins on the recurrence of Crohn's disease in the small bowel. A randomized controlled trial.242 cites
Xie J · 2008 · World J Gastroenterol · Cancer in inflammatory bowel disease.238 cites
Allez M · 2002 · Am J Gastroenterol · Long term outcome of patients with active Crohn's disease exhibiting extensive and deep ulcerations at colonoscopy.233 cites
Farrell RJ · 2000 · Gastroenterology · High multidrug resistance (P-glycoprotein 170) expression in inflammatory bowel disease patients who fail medical therapy.231 cites
Borruel N · 2002 · Gut · Increased mucosal tumour necrosis factor alpha production in Crohn's disease can be downregulated ex vivo by probiotic bacteria.230 cites
Cleynen I · 2013 · Gut · Genetic factors conferring an increased susceptibility to develop Crohn's disease also influence disease phenotype: results from the IBDchip European Project.229 cites
Burisch J · 2019 · Gut · Natural disease course of Crohn's disease during the first 5 years after diagnosis in a European population-based inception cohort: an Epi-IBD study.229 cites
Nguyen GC · 2017 · Gastroenterology · American Gastroenterological Association Institute Guideline on the Management of Crohn's Disease After Surgical Resection.228 cites
Stidham RW · 2018 · Clin Colon Rectal Surg · Colorectal Cancer in Inflammatory Bowel Disease.227 cites
Steward MJ · 2012 · Eur J Radiol · Non-perforating small bowel Crohn's disease assessed by MRI enterography: derivation and histopathological validation of an MR-based activity index.227 cites
Dickinson RJ · 1980 · Gastroenterology · Controlled trial of intravenous hyperalimentation and total bowel rest as an adjunct to the routine therapy of acute colitis.225 cites
Lawlor G · 2010 · Inflamm Bowel Dis · Cytomegalovirus in inflammatory bowel disease: pathogen or innocent bystander?223 cites
Jahnsen J · 1997 · Gut · Bone mineral density is reduced in patients with Crohn's disease but not in patients with ulcerative colitis: a population based study.223 cites
Neut C · 2002 · Am J Gastroenterol · Changes in the bacterial flora of the neoterminal ileum after ileocolonic resection for Crohn's disease.220 cites
Kasahara Y · 1981 · Dis Colon Rectum · Intestinal involvement in Behçet's disease: review of 136 surgical cases in the Japanese literature.219 cites
Rump JA · 1990 · Immunobiology · A new type of perinuclear anti-neutrophil cytoplasmic antibody (p-ANCA) in active ulcerative colitis but not in Crohn's disease.217 cites
Lipska MA · 2006 · ANZ J Surg · Anastomotic leakage after lower gastrointestinal anastomosis: men are at a higher risk.217 cites
Rimola J · 2015 · Am J Gastroenterol · Characterization of inflammation and fibrosis in Crohn's disease lesions by magnetic resonance imaging.217 cites
Lee EC · 1982 · Ann R Coll Surg Engl · Minimal surgery for chronic obstruction in patients with extensive or universal Crohn's disease.214 cites
Van Gossum A · 2007 · Inflamm Bowel Dis · Multicenter randomized-controlled clinical trial of probiotics (Lactobacillus johnsonii, LA1) on early endoscopic recurrence of Crohn's disease after lleo-caecal resection.213 cites
Høivik ML · 2013 · Gut · Work disability in inflammatory bowel disease patients 10 years after disease onset: results from the IBSEN Study.212 cites
Punwani S · 2009 · Radiology · Mural inflammation in Crohn disease: location-matched histologic validation of MR imaging features.209 cites
Silvennoinen JA · 1995 · Gut · A controlled study of bone mineral density in patients with inflammatory bowel disease.205 cites
Michelassi F · 1991 · Ann Surg · Primary and recurrent Crohn's disease. Experience with 1379 patients.203 cites
D'Haens G · 1997 · Gastroenterology · Healing of severe recurrent ileitis with azathioprine therapy in patients with Crohn's disease.203 cites
Cohen RD · 2002 · Aliment Pharmacol Ther · The quality of life in patients with Crohn's disease.202 cites
Benchimol EI · 2014 · Gastroenterology · Incidence, outcomes, and health services burden of very early onset inflammatory bowel disease.202 cites
Hellers G · 1999 · Gastroenterology · Oral budesonide for prevention of postsurgical recurrence in Crohn's disease. The IOIBD Budesonide Study Group.202 cites
Kraft SC · 1976 · Arch Intern Med · Unexplained bronchopulmonary disease with inflammatory bowel disease.201 cites
Rasmussen SN · 1982 · Gastroenterology · 5-aminosalicylic acid in a slow-release preparation: bioavailability, plasma level, and excretion in humans.201 cites
Choy PY · 2011 · Cochrane Database Syst Rev · Stapled versus handsewn methods for ileocolic anastomoses.197 cites