Top 100 Most-Disruptive Papers

The 100 most-disruptive papers by the Funk & Owen-Smith CD (disruption) index, which measures how much a paper redirected the field away from prior work. Papers under 5 years old are excluded.

The disruption index is unreliable for papers under 5 years old, so recent papers are excluded. A research reference for clinicians and trainees, not treatment advice.

  1. Lee EC · 1982 · Ann R Coll Surg Engl · Minimal surgery for chronic obstruction in patients with extensive or universal Crohn's disease.CD 0.76
  2. Hudson CN · 1972 · Proc R Soc Med · Ileostomy in pregnancy.CD 0.74
  3. Sladen GE · 1984 · Dis Colon Rectum · Is segmental colitis a complication of diverticular disease?CD 0.48
  4. Phillips EH · 1992 · Ann Surg · Laparoscopic colectomy.CD 0.30
  5. Hellers G · 1980 · Gut · Occurrence and outcome after primary treatment of anal fistulae in Crohn's disease.CD 0.29
  6. Quinn KP · 2020 · Am J Gastroenterol · An Update on the Medical Management of Inflammatory Pouch Complications.CD 0.22
  7. Puylaert JB · 2012 · Dig Dis · Ultrasound of colon diverticulitis.CD 0.22
  8. Alexander-Williams J · 1982 · Chirurg · ["Strictureplasty" in Crohn disease].CD 0.21
  9. Waye JD · 1977 · Gastrointest Endosc · The role of colonoscopy in the differential diagnosis of inflammatory bowel disease.CD 0.19
  10. Rutgeerts P · 1984 · Gut · Natural history of recurrent Crohn's disease at the ileocolonic anastomosis after curative surgery.CD 0.14
  11. Burman JH · 1971 · Gut · The effects of diversion of intestinal contents on the progress of Crohn's disease of the large bowel.CD 0.14
  12. Leenen LP · 1989 · Dis Colon Rectum · Some factors influencing the outcome of stoma surgery.CD 0.14
  13. Bartholdson L · 1975 · Scand J Plast Reconstr Surg · Repair of persistent perineal sinuses by means of a pedicle flap of musculus gracilis. Case report.CD 0.14
  14. Rutgeerts P · 1990 · Gastroenterology · Predictability of the postoperative course of Crohn's disease.CD 0.13
  15. Milsom JW · 2001 · Dis Colon Rectum · Prospective, randomized trial comparing laparoscopic vs. conventional surgery for refractory ileocolic Crohn's disease.CD 0.13
  16. Passaro E · 1976 · Am J Surg · Bypass enteritis. A new complication of jejunoileal bypass for obesity.CD 0.12
  17. Breysem Y · 1992 · Gastrointest Endosc · Endoscopic balloon dilation of colonic and ileo-colonic Crohn's strictures: long-term results.CD 0.12
  18. Tvede M · 1983 · Scand J Gastroenterol · Serum antibodies to Bacteroides species in chronic inflammatory bowel disease.CD 0.11
  19. Burman JH · 1971 · Gut · The fate of ileorectal anastomosis in Crohn's disease.CD 0.10
  20. Chapman RW · 1980 · Gut · Primary sclerosing cholangitis: a review of its clinical features, cholangiography, and hepatic histology.CD 0.10
  21. Greenstein AJ · 1976 · Medicine (Baltimore) · The extra-intestinal complications of Crohn's disease and ulcerative colitis: a study of 700 patients.CD 0.10
  22. Hultén L · 1971 · Acta Chir Scand · Primary closure of perineal wound after proctocolectomy or rectal excision.CD 0.09
  23. Milsom JW · 1993 · Surg Laparosc Endosc · Laparoscopically assisted ileocolectomy in Crohn's disease.CD 0.09
  24. Williams RN · 2009 · J Clin Pathol · Enteral Clostridium difficile, an emerging cause for high-output ileostomy.CD 0.09
  25. Irvin TT · 1973 · Br J Surg · Aetiology of disruption of intestinal anastomoses.CD 0.09
  26. Ludwig KA · 1996 · Am J Surg · Preliminary experience with laparoscopic intestinal surgery for Crohn's disease.CD 0.08
  27. Liu CD · 1995 · Am Surg · Laparoscopic surgery for inflammatory bowel disease.CD 0.08
  28. Yamamoto T · 2000 · Dis Colon Rectum · Risk factors for intra-abdominal sepsis after surgery in Crohn's disease.CD 0.08
  29. Dunker MS · 1998 · Surg Endosc · Cosmesis and body image after laparoscopic-assisted and open ileocolic resection for Crohn's disease.CD 0.08
  30. Colcock BP · 1973 · Surg Clin North Am · Operative technique in surgery for Crohn's disease and its relationship to recurrence.CD 0.07
  31. Kraft SC · 1976 · Arch Intern Med · Unexplained bronchopulmonary disease with inflammatory bowel disease.CD 0.07
  32. Cho S · 2019 · J Pediatr Gastroenterol Nutr · Fecal Microbiota Transplant for Recurrent Clostridium difficile Infection in Pediatric Inflammatory Bowel Disease.CD 0.07
  33. Ritchie JK · 1974 · Br Med J · Results of surgery for inflammatory bowel disease: a further survey of one hospital region.CD 0.07
  34. Berliner L · 1982 · Am J Gastroenterol · Computed tomography in Crohn's disease.CD 0.06
  35. Rutgeerts P · 1991 · Lancet · Effect of faecal stream diversion on recurrence of Crohn's disease in the neoterminal ileum.CD 0.06
  36. TRUELOVE SC · 1965 · Br Med J · PLACE OF A DOUBLE-BARRELLED ILEOSTOMY IN ULCERATIVE COLITIS AND CROHN'S DISEASE OF THE COLON: A PRELIMINARY REPORT.CD 0.06
  37. Thota VR · 2011 · Future Microbiol · Eggerthella lenta bacteremia in a Crohn's disease patient after ileocecal resection.CD 0.06
  38. Galandiuk S · 1995 · Arch Surg · A surgical subspecialist enhances general surgical operative experience.CD 0.05
  39. Buchmann P · 1980 · Am J Surg · Natural history of perianal Crohn's disease. Ten year follow-up: a plea for conservatism.CD 0.05
  40. Kelly JK · 1989 · J Clin Gastroenterol · Origin of fistulas in Crohn's disease.CD 0.04
  41. Deutsch AA · 1991 · Dis Colon Rectum · Results of the pelvic-pouch procedure in patients with Crohn's disease.CD 0.04
  42. Heimann TM · 1985 · Ann Surg · Early complications following surgical treatment for Crohn's disease.CD 0.04
  43. Flake WK · 1979 · Am J Surg · Problems encountered with the Kock ileostomy.CD 0.04
  44. Schofield PF · 1972 · Proc R Soc Med · Intestinal malignancy and Crohn's disease.CD 0.04
  45. Hurst RD · 1997 · Surgery · Prospective study of the features, indications, and surgical treatment in 513 consecutive patients affected by Crohn's disease.CD 0.04
  46. Price AB · 1978 · J Clin Pathol · Overlap in the spectrum of non-specific inflammatory bowel disease--'colitis indeterminate'.CD 0.04
  47. Harper PH · 1985 · Gut · Role of the faecal stream in the maintenance of Crohn's colitis.CD 0.04
  48. Karkos CD · 2001 · Ann Emerg Med · Use of the intra-aortic balloon pump to stop gastrointestinal bleeding.CD 0.04
  49. Andrews HA · 1989 · Br J Surg · Prognosis after surgery for colonic Crohn's disease.CD 0.04
  50. Kirkegaard P · 1983 · Am J Surg · Perineal sinus after removal of the rectum. Occlusion with fibrin adhesive.CD 0.03
  51. Lindor KD · 1985 · Mayo Clin Proc · Preoperative nutritional status and other factors that influence surgical outcome in patients with Crohn's disease.CD 0.03
  52. Allan R · 1975 · Gut · Changes in the bidirectional sodium flux across the intestinal mucosa in Crohn's disease.CD 0.03
  53. Carlstedt A · 1987 · Int J Colorectal Dis · Long-term ileostomy complications in patients with ulcerative colitis and Crohn's disease.CD 0.03
  54. Nyhlin H · 1994 · Gut · Bile acid malabsorption in Crohn's disease and indications for its assessment using SeHCAT.CD 0.03
  55. Fallingborg J · 1999 · Dan Med Bull · Intraluminal pH of the human gastrointestinal tract.CD 0.03
  56. Yamamoto T · 1999 · Am J Surg · Factors affecting the incidence of postoperative septic complications and recurrence after strictureplasty for jejunoileal Crohn's disease.CD 0.03
  57. Leong AP · 1994 · Br J Surg · Life-table analysis of stomal complications following ileostomy.CD 0.03
  58. Mughal M · 1986 · Lancet · Home parenteral nutrition in the United Kingdom and Ireland.CD 0.03
  59. Ellozy SH · 2002 · Dis Colon Rectum · Early postoperative small-bowel obstruction: a prospective evaluation in 242 consecutive abdominal operations.CD 0.03
  60. Spark RP · 1976 · Am J Dig Dis · Filiform polyposis of the colon. First report in a case of transmural colitis (Crohn's disease).CD 0.03
  61. Schoetz DJ · 1997 · Dis Colon Rectum · "Ideal" length of stay after colectomy: whose ideal?CD 0.02
  62. Procaccino JA · 1991 · Dis Colon Rectum · Psoas abscess: difficulties encountered.CD 0.02
  63. Bergan T · 1981 · Chemotherapy · Pharmacokinetics of metronidazole in patients with enteric disease compared to normal volunteers.CD 0.02
  64. Hill GL · 1974 · Gut · Impairment of 'ileostomy adaptation' in patients after ileal resection.CD 0.02
  65. Farmer RG · 1976 · Gastroenterology · Indications for surgery in Crohn's disease: analysis of 500 cases.CD 0.02
  66. Frøslie KF · 2007 · Gastroenterology · Mucosal healing in inflammatory bowel disease: results from a Norwegian population-based cohort.CD 0.02
  67. Wikland M · 1990 · Int J Colorectal Dis · Gynaecological problems related to anatomical changes after conventional proctocolectomy and ileostomy.CD 0.02
  68. Roslyn JJ · 1983 · Gastroenterology · Gallbladder disease in patients on long-term parenteral nutrition.CD 0.02
  69. Tchirkow G · 1983 · Dis Colon Rectum · Crohn's disease in the elderly.CD 0.02
  70. Faulconer HT · 1975 · Dis Colon Rectum · Rectovaginal fistula in patients with colitis: review and report of a case.CD 0.02
  71. Duerksen DR · 2006 · Nutrition · Vitamin B12 malabsorption in patients with limited ileal resection.CD 0.02
  72. Otterson MF · 2004 · Surgery · Radiographic underestimation of small bowel stricturing Crohn's disease: a comparison with surgical findings.CD 0.02
  73. Brewer DB · 1990 · J Pathol · Axonal damage in Crohn's disease is frequent, but non-specific.CD 0.02
  74. Anderson R · 1976 · Arch Surg · Grafting the unhealed perineal wound after coloproctectomy for Crohn disease.CD 0.02
  75. Scott NA · 1994 · Gut · Timing of ileocolonic resection for symptomatic Crohn's disease--the patient's view.CD 0.02
  76. Gemlo BT · 1992 · Arch Surg · Ileal pouch-anal anastomosis. Patterns of failure.CD 0.02
  77. Corman ML · 1978 · Dis Colon Rectum · Impotence after proctectomy for inflammatory disease of the bowel.CD 0.02
  78. Jones B · 1986 · J Comput Assist Tomogr · Submucosal accumulation of fat in inflammatory bowel disease: CT/pathologic correlation.CD 0.02
  79. Cannom RR · 2009 · Am Surg · Inflammatory bowel disease in the United States from 1998 to 2005: has infliximab affected surgical rates?CD 0.02
  80. Fazio V · 1975 · Dis Colon Rectum · Ileorectal anastomosis: a safe surgical technique.CD 0.02
  81. Rogler G · 2010 · Best Pract Res Clin Gastroenterol · Gastrointestinal and liver adverse effects of drugs used for treating IBD.CD 0.02
  82. Kock NG · 1971 · Ann Surg · Ileostomy without external appliances: a survey of 25 patients provided with intra-abdominal intestinal reservoir.CD 0.02
  83. Kasahara Y · 1981 · Dis Colon Rectum · Intestinal involvement in Behçet's disease: review of 136 surgical cases in the Japanese literature.CD 0.02
  84. Palder SB · 1991 · J Pediatr Surg · Perianal complications of pediatric Crohn's disease.CD 0.02
  85. Finegold SM · 1970 · J Infect Dis · The normal flora of ileostomy and transverse colostomy effluents.CD 0.02
  86. Weston LA · 1996 · Dis Colon Rectum · Ileocolic resection for acute presentation of Crohn's disease of the ileum.CD 0.02
  87. Dutta S · 2003 · J Pediatr Surg · Total intracorporeal laparoscopic resection of Crohn's disease.CD 0.02
  88. Høivik ML · 2013 · Gut · Work disability in inflammatory bowel disease patients 10 years after disease onset: results from the IBSEN Study.CD 0.02
  89. Wagtmans MJ · 2001 · Am J Gastroenterol · Gender-related differences in the clinical course of Crohn's disease.CD 0.02
  90. Oliveira L · 1997 · Surg Endosc · Laparoscopic creation of stomas.CD 0.01
  91. Savage MO · 1999 · Acta Paediatr Suppl · Growth in Crohn's disease.CD 0.01
  92. Cosnes J · 2011 · Gastroenterology · Epidemiology and natural history of inflammatory bowel diseases.CD 0.01
  93. Kusunoki M · 1998 · Dig Surg · A comparison of stapled and hand-sewn anastomoses in Crohn's disease.CD 0.01
  94. Swenson BR · 2005 · Dis Colon Rectum · Modified two-stage ileal pouch-anal anastomosis: equivalent outcomes with less resource utilization.CD 0.01
  95. Luglio G · 2019 · Tech Coloproctol · Stapled versus handsewn methods for ileocolic anastomoses.CD 0.01
  96. Rhoads JE · 1970 · Med Clin North Am · Intravenous hyperalimentation.CD 0.01
  97. Marin ML · 1983 · Am J Gastroenterol · A freeze fracture study of Crohn's disease of the terminal ileum: changes in epithelial tight junction organization.CD 0.01
  98. Goldstone RN · 2019 · Surg Clin North Am · Abdominal Emergencies in Inflammatory Bowel Disease.CD 0.01
  99. Baker WN · 1971 · Gut · Ileo-rectal anastomosis for Crohn's disease of the colon.CD 0.01
  100. Andrews HA · 1991 · Br J Surg · Strategy for management of distal ileal Crohn's disease.CD 0.01